IMTIB   27019
INSTITUTO DE MEDICINA TRASLACIONAL E INGENIERIA BIOMEDICA
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
PEDIATRIC AND ADULT NON ALCOHOLIC FATTY LIVER DISEASE (NAFLD) PATHOGENIA: LYMPHOCYTE POPULATIONS CHARACTERIZATION IN THE LIVER MICROENVIRONMENT
Autor/es:
GIADANS C; MULLEN E; GALOPPO M; VALVA P; DE MATTEO E; AMEIGEIRAS B; LEZAMA C; PRECIADO MV; CAIROLI V; CASCIATO P; PEDREIRA A; BERTOT G
Lugar:
Glasgow
Reunión:
Congreso; 32nd Congress of the ESP and XXXIII International Congress of the IAP; 2020
Institución organizadora:
European Society of Pathology - International Academy of Pathology
Resumen:
The immune system is one of the main drivers of NAFLD pathogenesis, but the role of eachliver lymphocyte populationof the infiltrate in the pathogenesis is uncertain. Aim: to characterize liver infiltrate in relation to histological damage in NAFLD patients.Twenty-six paediatric[11.5 yrs (4-17)] and 34 adult NAFLD patients [50yrs (28-72)] were enrolled. On liver biopsies histological changes as well as T helpers Lymphocyte (Th), Cytotoxic T Lymphocytes (CTL), Regulatory T lymphocytes(Treg) and Th17 localization and frequency were evaluated.Statistical analysis were performed to assessthe relation between the immune response and the observed damage.Portal-periportal-CTL and -Th frequencies were similar in paediatric and adult NAFLD cases. Th17 seemed to be nearly exclusive of this location. In children Treg and Th17 counts were comparable,but in adults Tregswere higher than Th17cells. In intralobular area CTL>Th>Treg predominance was observed both agegroup. Comparison between themdemonstratedhigherportal-periportal-Treg (p