IMTIB   27019
INSTITUTO DE MEDICINA TRASLACIONAL E INGENIERIA BIOMEDICA
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
The thyroid status modulates the tumor microenvironment and the antitumor immune response in breast cancer
Autor/es:
GUTIERREZ L; DÍAZ FLAQUÉ MC; CREMASCHI GA; HILDEBRANDT X; CAYROL MF; BOLONTRADE M; STERLE HA; PAULAZO MA; ROSEMBLIT C
Lugar:
Buenos Aires
Reunión:
Congreso; XVII Latin American Thyroid Society Congress; 2019
Institución organizadora:
Latin American Thyroid Society
Resumen:
Introduction:Several findings suggest that the patient?s hormonal context plays a crucial role in determining the outcome of cancer. However, very little is known about the nature of thyroid hormone action on tumor growth. AIM:To evaluate the effect of thyroid status on triple negative breast cancer (TNBC) development. MethodsBalb/c mice were orthotopically inoculated with 4T1 cells after the treatment with thyroxine (12mg/l) for 30 days or propylthiouracil (500mg/l) for 15 days in the drinking water to obtain hyperthyroid (hyper) or hypothyroid (hypo) mice, respectively. ResultsHyper mice showed increased tumor growth rate compared to controls (p