Virus–Host Interactions Involved in Lassa Virus Entry and Genome Replication

LÓPEZ, NORA; LOUREIRO, MARÍA; D?ANTUONO, ALEJANDRA

Pathogens

MDPI

Lugar: Basel; Año: 2019 vol. 8

Abstract: Lassa virus (LASV) is the causative agent of Lassa fever, a human hemorrhagic disease associated with high mortality and morbidity rates, particularly prevalent in West Africa. Over the past few years, a significant amount of novel information has been provided on cellular factors that are determinant elements playing a role in arenavirus multiplication. In this review, we focus on host proteins that intersect with the initial steps of the LASV replication cycle: virus entry and genomereplication. Abetterunderstandingofrelevantvirus?hostinteractionsessentialforsustaining these critical steps may help to identify possible targets for the rational design of novel therapeutic approaches against LASV and other arenaviruses that cause severe human disease.