CIBAAL   26918
CENTRO DE INVESTIGACION EN BIOFISICA APLICADA Y ALIMENTOS
Unidad Ejecutora - UE
artículos
Título:
A new model for lipid monolayer and bilayers based on thermodynamics of irreversible processes
Autor/es:
DISALVO E.A.; PINTO O. A
Revista:
PLOS ONE
Editorial:
PUBLIC LIBRARY SCIENCE
Referencias:
Lugar: San Francisco; Año: 2019 vol. 14 p. 1 - 25
ISSN:
1932-6203
Resumen:
Lipid monolayers are used as experimental model systems to study the physical chemicalproperties of biomembranes. With this purpose, surface pressure/area per molecule isothermsprovide a way to obtain information on packing and compressibility properties of thelipids. These isotherms have been interpreted considering the monolayer as a two dimensionalideal or van der Waals gas without contact with the water phase. These modelisticapproaches do not fit the experimental results. Based on Thermodynamics of IrreversibleProcesses (TIP), the expansion/compression process is interpreted in terms of coupledphenomena between area changes and water fluxes between a bidimensional solution ofhydrated head groups in the monolayer and the bulk solution. The formalism obtained canreproduce satisfactorily the surface pressure/area per lipid isotherms of monolayer in different states and also can explain the area expansion and compression produced in particles enclosed by bilayers during osmotic fluxes. This novel approach gives relevance to the lipidwater interaction in restricted media near the membrane and provides a formalism to understand the thermodynamic and kinetic response of biointerphases to biological effectors.