CIBAAL   26918
CENTRO DE INVESTIGACION EN BIOFISICA APLICADA Y ALIMENTOS
Unidad Ejecutora - UE
artículos
Título:
Effects of Phenylalanine on the Liquid-Expanded and Liquid-Condensed States of Phosphatidylcholine Monolayers
Autor/es:
CUTRO, ANDREA C; FRÍAS, MARÍA A; DISALVO, E ANIBAL
Revista:
Lipid Insights
Editorial:
Sage Publishing
Referencias:
Lugar: California; Año: 2019 vol. 12
ISSN:
1178-6353
Resumen:
Phenylalanine (Phe) is involved in physiological and pathological processes in cell membranes in which expanded andcondensed states coexist. In this direction, it was reported that surface hydration is important for the binding affinity of the amino acid whichsignificantly perturbs 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) monolayer structure and morphology. A deeper insight showed that Phe inserts in DPPC monolayer defects as a monomer at pH 5 and forms aggregates that adsorb to the membrane surface generating a reconfiguration of the lipid arrangement in areas of higher packing. This new arrangement in the monolayer causes the reorientation of dipoles of lipid and water molecules which is congruent with the dehydration and surface tension changes reported above. With this background, this article studies the affinity of Phe in liquid-expanded 1,2-dimyristoyl-sn-glycero-3 phosphocholine (LE DMPC) and liquid-condensed 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (LC DPPC) monolayers and their effects on membrane properties.