Glial Modulation by N-acylethanolamides in Brain Injury and Neurodegeneration

HERRERA MI, KÖLLIKER-FRERS R, BARRETO G3, BLANCO E4, CAPANI F5.

. Front Aging Neurosci

Frontiers in Neuroscience

Año: 2016

Neuroinflammation involves the activation of glial cells and represents a key element in normal aging and pathophysiology of brain damage. N-acylethanolamides (NAEs), naturally occurring amides, are known for their pro-homeostatic effects. An increase in NAEs has been reported in vivo and in vitro in the aging brain and in brain injury. Treatment with NAEs may promote neuroprotection and exert anti-inflammatory actions via PPARα activation and/or by counteracting gliosis. This review aims to provide an overview of endogenous and exogenous properties of NAEs in neuroinflammation and to discuss their interaction with glial cells.