CEMIC - CONICET   26185
CENTRO DE EDUCACION MEDICA E INVESTIGACIONES CLINICAS "NORBERTO QUIRNO"
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Patterns of Dental Anomalies in Orofacial Clefting using Hierarchical Clustering.
Autor/es:
WANG T; ORIOLI IM; HOWE BJ; XIE JX; POLETTA FA; MORENO URIBE, LINA M.; ZENG E; HECHT JT; MARAZITA ML
Lugar:
Vancouver
Reunión:
Congreso; 97th IADR/AADR/CADR General Session & Exhibition; 2019
Institución organizadora:
IADR/AADR/CADR
Resumen:
Objectives: Children born with orofacial clefts (OFC) present increased rates (51%) of multiple dental anomalies compared to the general population (8%). Little is known on whether patterns exist within and among dental anomalies and how race, gender, cleft type, and cleft laterality factor into those patterns. This study examines patterns of dental anomalies in a multi-ethnic cohort of children with nonsyndromic OFC, their relatives, and controls.Methods: From a total of 1,794 individuals included from 8 international sites: 1,119 individuals were either affected with an overt cleft or seemingly unaffected but likely to carry OFC risk due to family history (unaffected relatives). The remaining 675 individuals with no OFC history were controls. Dental anomalies were identified from in-person dental exams. Teeth were numbered using the FDI World Dental Federation notation. Patterns were identified within each sample using hierarchical clustering, an unsupervised learning algorithm that identifies subject-anomaly clusters that share similar patterns. The clustering results were visualized using the bioinformatics tool Multiple Experiment Viewer.Results: Preliminary analysis of subjects with overt clefts or cleft risk identified 4 clusters with tooth agenesis as the prominent anomaly. All subjects within clusters were unrelated. Cluster 1: Groups individuals with agenesis of primary left maxillary lateral incisor (#62), female, cleft lip and palate (CLP) and hypoplasia; Cluster 2: Agenesis of both maxillary permanent lateral incisors (#12, 22) and CLP; Cluster 3: Agenesis of premolars (#15, 25, 35, 45), unaffected family members; Cluster 4: Agenesis of permanent maxillary left lateral incisor (#22), CLP. Clusters of control subjects showed tooth malposition as the prominent feature; yet, groupings were sparser and without clear patterns.Conclusions: Clusters of dental anomalies were identified suggesting unique patterns in the primary and permanent dentition that are predictive and descriptive of agenesis. Phenotypic similarity of subjects with-in each cluster suggests similar genetic etiology.