CONICET | Buscador de Institutos y Recursos Humanos

The identification of new major congenital anomalies complexes and associations is an important activity in birth defects surveillance. To date, two approaches have been used to analyze associations. The first focuses on a specific anomaly and determines the association degree with other anomalies. The second approach was based on the cases clustering considering each anomaly as a binary variable. The graph theory, offers an integrating approach, allows to analyze the complete set of anomalies and each of them in particular. A graph is constituted by nodes that represent entities and edges that represent the relationship between entities. In recent years this approach has enriched many study areas, for example, proteins interactions and diseases associations. The objective of this work is to analyze the feasibility of this approach to study major anomalies complexes and associations.