CEMIC - CONICET   26185
CENTRO DE EDUCACION MEDICA E INVESTIGACIONES CLINICAS "NORBERTO QUIRNO"
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Estudio de asociación entre polimorfismos específicos y subtipos clínicos de parto pretérmino mediante la plataforma FLUIDIGM genotyping
Autor/es:
MURRAY JC; KRUPITZKI H; RATOWIECKI J; GILI JA; GADOW EC; SALEME C; BUSCH T; MOMANY AM; LOPEZ CAMELO JS; CASTILLA EE; COSENTINO V; POLETTA FA; GIMENEZ L
Reunión:
Congreso; Congreso por una ciencia de pie; 2017
Resumen:
Pretermbirth (PTB) is the leading cause of perinatalmorbidity and mortality worldwide. The etiology of PTB is multi-factorial, heterogeneous, and there is strong evidence of genetic susceptibility. The aim of this work was to investigate the association between 24 single nucleotide polymorphism(SNPs) and the different clinical subtypes of pretermbirth: spontaneous (PTB-I), premature rupture ofmembrane (PTB-PROM) and medically indicated (PTB-M). These SNPs have been previously studied in a heterogeneous group of PTBs. Methods. The sample included 674 triads (proband, mother, father) recruited at the Nuestra Señora de la Merced Maternity Hospital in Tucumán, Argentina. Of these triads, 233 had probands from PTB-I, 241 had probands from PTB-PROM and 200 had probands from PTB-M. We studied 24 SNPs in 18 candidate genes. Genotyping was performed using Applied Biosystems Taqman probes and the Fluidigmgenotyping platform. SNPs were chosen based on previous reports of significant association with preterm birth. Data were analyzed using the Transmission Disequilibrium Test (TDT) (Spielman et al. 1993). The p values (