CEMIC - CONICET 26185
CENTRO DE EDUCACION MEDICA E INVESTIGACIONES CLINICAS "NORBERTO QUIRNO"
Unidad Ejecutora - UE
artículos
Título:
Efficacy and safety of direct-acting antiviral agents for HCV in mild-to-moderate chronic kidney disease
Autor/es:
RIDRUEJO, EZEQUIEL; AOUFI-RABIH, SAMI; FABRIZI, FABRIZIO; GARCIA-AGUDO, REBECA; DIXIT, VIVEK; MENDIZABAL, MANUEL; SILVA, MARCELO
Revista:
NEFROLOGIA
Editorial:
SOC ESPANOLA NEFROLOGIA DR RAFAEL MATESANZ
Referencias:
Año: 2019
ISSN:
0211-6995
Resumen:
BACKGROUND AND AIMS:The advent of direct-acting antiviral agents promises to change the management of hepatitis C virus infection (HCV) in patients with chronic kidney disease (CKD), a patient group in which the treatment of hepatitis C was historically challenging. We investigated the safety and efficacy of all-oral, interferon-free direct-acting antiviral agents for the treatment of hepatitis C in a 'real-world' cohort of patients with CKD.METHODS:We performed an observational single-arm multi-centre study in a large (n=198) cohort of patients with stage 1-3 CKD who underwent antiviral therapy with DAAs for the treatment of HCV. The primary end-point was sustained virologic response (serum HCV RNA
