CEMIC - CONICET 26185
CENTRO DE EDUCACION MEDICA E INVESTIGACIONES CLINICAS "NORBERTO QUIRNO"
Unidad Ejecutora - UE
artículos
Título:
Polymorphisms in NR5A2, gene encoding liver receptor homolog-1 are associated with preterm birth
Autor/es:
MURRAY, JEFFREY C.; CHRISTENSEN, KAARE; GIMENEZ, LUCAS G.; KALUARACHCHI, DINUSHAN C.; DAGLE, JOHN M.; SALEME, CESAR; MOMANY, ALLISON M.; RYCKMAN, KELLI K.; COSENTINO, VIVIANA; BUSCH, TAMARA D.
Revista:
PEDIATRIC RESEARCH
Editorial:
INT PEDIATRIC RESEARCH FOUNDATION, INC
Referencias:
Año: 2018 vol. 79 p. 776 - 780
ISSN:
0031-3998
Resumen:
BACKGROUND:Preterm birth (PTB) is a major cause of neonatal mortality and morbidity. There is strong evidence of genetic susceptibility. Objective of this study was to identify genetic variants contributing to PTB.METHODS:Genotyping was performed for 24 single nucleotide polymorphisms (SNPs) in 4 candidate genes (NR5A2, FSHR, FOXP3, and SERPINH1). Genotyping was completed on 728 maternal triads (mother and maternal grandparents of a preterm infant). Data were analyzed with Family Based Association Test.RESULTS:For all maternal triads rs2737667 of NR5A2 showed significant association at P = 0.02. When stratifying by gestational age three SNPs in NR5A2 had P values
