Epidemiology of early repolarization pattern in an adult general population

GARCÍA-ZAMORA, SEBASTIÁN; IRAZOLA, VILMA EDITH; GULAYIN, PABLO ELIAS; RUBINSTEIN, ADOLFO LUIS; GONZALEZ-ZUELGARAY, JORGE; MATTA, MARÍA GABRIELA; GUTIERREZ, LAURA; POGGIO, ROSANA

ACTA CARDIOLOGICA

ACTA CARDIOLOGICA

Lugar: Buenos Aires; Año: 2019 p. 1 - 11

0001-5385

ABSTRACTBackground: Early repolarization pattern (ERP) is a frequent finding in asymptomatic subjectswith controversial implications regarding to its prognosis. This study aims to estimate the prevalenceof ERP and its association with sociodemographic characteristics and cardiovascular riskfactors among the adult population in the Southern Cone of Latin America.Methods: A sub-sample of 5398 participants of the CESCAS I study was included in the presentanalysis. ERP was defined as a J peak 0.1mV in two or more contiguous leads with an end-QRS notch or slur on the downslope of a prominent R-wave.Results: The global prevalence of ERP was 8.1%; 11.1% in men and 5.6% in women. The prevalencein women increased with age (odds ratio [OR] 2.5, 95% confidence interval [CI] 1.5?4.2, at>65 years, p<0.001), current cigarette smoking (OR 1.4, 95%CI 1.0?2.0, p¼0.045) and hypercholesterolaemia(OR 1.4, 95%CI 1.0?2.0, 0 p¼0.036). Conversely, in men, ERP prevalencedecreased with age (OR 0.5, 95%CI 0.3?0.9, at >65 years, p¼0.01) and obesity (OR 0.6, 95%CI0.4?0.8, p¼0.006). We found an increasing ERP prevalence with a higher Sokolow-Lyon index inboth sexes (p<0.001). Inferior location was found in 67.9% of cases, and the most common ERPtype was a ?slurring? appearance without ST elevation (76.3%).Conclusions: We found an overall prevalence of ERP of 8.1% and a robust association of ERPwith normal BMI and higher Sokolow-Lyon index in men and with hypercholesterolaemia, currentcigarette smoking and higher Sokolow-Lyon index in women.