PERSONAL DE APOYO
CAMICIA Gabriela Lorena
artículos
Título:
Increases in IgA+ B cells in Peyer's patches during milk-borne mouse mammary tumor virus infection are influenced by Toll-like receptor 4 and are completely dependent on the superantigen response
Autor/es:
CABRERA G; VERCELLI C; D BURZYN; BADANO MN; A.F. MAGLIOCO; COSTA H; J MUNDIÑANO; CAMICIA G; I NEPOMNASCHY; I PIAZZON
Revista:
JOURNAL OF GENERAL VIROLOGY
Editorial:
SOC GENERAL MICROBIOLOGY
Referencias:
Lugar: London; Año: 2010
ISSN:
0022-1317
Resumen:
Mouse mammary tumor virus (MMTV) is a milk-borne betaretrovirus that has developed strategiesto exploit and subvert the host immune system. Although mammary glands are the final target ofinfection, Peyer?s patches (PP) are the entry site of the virus. Herein, we show that the infectioninduces increases in the number of PP IgA+ B cells and higher expression of the a circulartranscript, which is a specific marker of the switch to IgA. In addition, IgA+ B-cell increasescorrelated with higher levels of cytokines related to IgA class switching, such as interleukin (IL)-5and IL-6. Of interest, the increases in IgA+ B cells were lower in Toll-like receptor 4-deficientmice and were completely dependent on the presence of superantigen-reactive T cells. Ourresults point to a novel mechanism involved in MMTV infection and suggest that IgA+ B cells mayplay an important role in carrying the virus to the mammary glands.