INVESTIGADORES
SOCIAS Sergio Benjamin
artículos
Título:
Novel tactics for neuroprotection in Parkinson?s disease: Role of antibiotics, polyphenols and neuropeptides
Autor/es:
REGLODI, D.; RENAUD, J.; TAMAS, A.; TIZABI, Y.; SOCIAS, S.B.; DEL-BEL, E.; RAISMAN VOZARI, R.
Revista:
PROGRESS IN NEUROBIOLOGY
Editorial:
PERGAMON-ELSEVIER SCIENCE LTD
Referencias:
Lugar: Amsterdam; Año: 2017 vol. 155 p. 120 - 148
ISSN:
0301-0082
Resumen:
Parkinson?s disease is a progressive neurodegenerative disorder characterized by the degeneration ofmidbrain nigral dopaminergic neurons. Although its etiology remains unknown, the pathological role ofseveral factors has been highlighted, namely oxidative stress, neuroinflammation, protein misfolding,and mitochondrial dysfunction, in addition to genetic predispositions. The current therapy is mainlysymptomatic with L-DOPA aiming to replace dopamine. Novel therapeutic approaches are beinginvestigated with the intention of influencing pathways leading to neuronal death and dysfunction. Thepresent review summarizes three novel approaches, the use of which is promising in pre-clinical studies.Polyphenols have been shown to possess neuroprotective properties on account of their well-establishedantioxidative and anti-inflammatory actions but also due to their influence on protein misfolding andmitochondrial homeostasis. Within the amazing ancillary effects of antibiotics, their neuroprotectiveproperties against neurodegenerative and neuroinflammatory processes are of great interest for thedevelopment of effective therapies against Parkinson?s disease. Experimental evidence supports thepotential of antibiotics as neuroprotective agents, being useful not only to prevent the formation of toxica-synuclein oligomers but also to ameliorate mitochondrial dysfunction and neuroinflammation.Neuropeptides offer another approach with their diverse effects in the nervous system. Among them,pituitary adenylate cyclase-activating polypeptide, a member of the secretin/glucagon superfamily, hasseveral advantageous effects in models of neurodegeneration, namely anti-apoptotic, anti-inflammatoryand antioxidant actions, the combination of which offers a potent protective effect in dopaminergicneurons. Owing to their pleiotropic modes of action, these novel therapeutic candidates have potential intackling the multidimensional features of Parkinson?s disease.