INSTITUTO DE INVESTIGACIONES EN RECURSOS NATURALES Y SUSTENTABILIDAD JOSE SANCHEZ LABRADOR S.J.
Unidad Ejecutora - UE
Maropitant administered orally 2-2.5 hours prior to morphine and dexmedetomidine reduces the incidence of emesis in cats
BOESCH JORDYN; KIRCH PATI; MASTROCCO ALICIA; STONE MARISA; LORENZUTTI AUGUSTO MATÍAS; LEARN MCKENZIE; CAMPOY LUIS; MARTÍN FLORES MANUEL
JOURNAL OF FELINE MEDICINE AND SURGERY
Año: 2017 vol. 19 p. 876 - 879
Objectives The main goal of this study was to test the antiemetic effects of maropitant administered orally 2?2.5 h prior to morphine and dexmedetomidine in cats.Methods Eighty-three healthy female cats were randomized to receive maropitant (8 mg orally; n = 39) or no treatment (control; n = 44), 2?2.5 h prior to morphine 0.1 mg/kg and dexmedetomidine 20 μg/kg intramuscularly. The incidence of sialorrhea, lip licking, retching and vomiting was recorded after morphine/dexmedetomidine injection.Results There were no differences between groups in terms of age or weight. The treated group received a mean ± SD dose of maropitant of 2.9 ± 0.6 mg/kg. The incidence of sialorrhea and lip licking was no different between groups. The incidence of retching (control 36% vs maropitant 13%; P = 0.012) and emesis (control 32% vs maropitant 13%; P = 0.03) were significantly reduced in cats treated with maropitant.Conclusions and relevance Maropitant 8 mg (total dose) administered orally 2?2.5 h prior to morphine and dexmedetomidine significantly reduced, but did not eliminate, the incidences of retching and vomiting. Maropitant did not decrease the occurrence of sialorrhea and lip licking, signs that may be indicative of nausea. Maropitant might be useful for morning administration to prevent emesis in outpatient cats requiring sedation or anesthesia; however, dose regimes or interval of administration might require improvement.