THE ROLE OF SLOW WAVE SLEEP IN MEMORY RECONSOLIDATION

PEDREIRA MARIA EUGENIA; FORCATO CECILIA; MOYANO MALEN; BORN JAN; JORGE CAMILA; DIEKELMANN SUSANNE

Congreso; XXXIII CONGRESO ANUAL SAN 2018; 2018

After acquisition memories are in a labile state. Thus, to persist in time they need to stabilize, a process known as consolidation. Once consolidated they can enter a new labile state after the presentation of a reminder (cue) of the original memory, followed by a period of re-stabilization (reconsolidation). If an amnesic agent is presented inside the reconsolidation time window (when the memory is still labile), the re-stabilization is affected. However, if it presented outside (~ 10 hours after the reminder), it has no effect on re-stabilization. Sleep is known to support the consolidation of newly encoded memories and it is also suggested that sleep has a beneficial effect on reconsolidation. Here, we ask whether sleep accelerates re-stabilization of consolidated memories protecting reactivated memories against interferences.