ENYS   25968
UNIDAD EJECUTORA DE ESTUDIOS EN NEUROCIENCIAS Y SISTEMAS COMPLEJOS
Unidad Ejecutora - UE
artículos
Título:
A controlled trial comparing one-year biochemical bone metabolism outcome in postmenopausal frail osteopenic women under weekly alendronate treatment, with or without whole-body vibration intervention
Autor/es:
RICARDO CAPIGLIONI; RICARDO CAPIGLIONI, CLAUDIA GOMEZ ACOTTO, ALICIA MARINO, MARÍA GEORGINA MUNTAABSKI, VICTOR MONTANGERO, LUCIANA D´ ALESSIO, EMILIO JOSÉ ANTONIO ROLDÁN
Revista:
Journal of Frailty, Sarcopenia and Falls
Editorial:
Hylonome Editions
Referencias:
Año: 2016 vol. 1 p. 1 - 8
ISSN:
2459-4148
Resumen:
Purpose: The influence of regular exercise on bone properties is not well defined. Frail subjects have limitationsto perform exercise with skeletal impact. This study aims to analyze whole-bone vibration treatment (WBV) as anenhancer of bisphosphonate effects in postmenopausal frail women with osteopenia/osteoporosis. Methods: Fiftythree postmenopausal sedentary osteopenic women were treated during 12 months with a drinkable alendronate(ALN) formulation. By randomization, 21 of them underwent a WBV (15-min sessions, 3 days per week) as anadditional treatment. The serum C-terminal telopeptide of type I collagen (CTx) and total alkaline phosphatase (TAP) were determined at 0, 6 and 12 months of ALN therapy. In subgroups of 19/13 women, peripheral quantitativecomputerized tomography (pQCT) was applied at the tibia mid shaft to determine the volumetric BMD of corticalbone (CtBMDv) and the polar strain-strength index (SSIp). Results: CTx levels fell significantly deeper in the WBVsubgroup (-39.3% and -30.3%, respectively, p