INVESTIGADORES
LOPEZ Fabian Enrique
artículos
Título:
Epidemiological study of prevalent pathogens in the Northwest region of Argentina (NWA)
Autor/es:
MÓNICA F. TORREZ LAMBERTI; LOPEZ FABIAN E; ANA BIANCHI; EVANGELINA BARRIONUEVO MEDINA; VALDEZ PATRICIA; MARÍA DE LAS MERCEDES PESCARETTI; DELGADO, MONICA A.
Revista:
PLOS ONE
Editorial:
PUBLIC LIBRARY SCIENCE
Referencias:
Lugar: San Francisco; Año: 2020
ISSN:
1932-6203
Resumen:
Northwest Argentina (NWA) is a poor economic-geographical region, with the highest rateof diarrhea diseases. At the moment, there are no reports showing the epidemiological statusof this region that would allow to establish methods for prevention and control of theseinfections and to indicate of the prevalent pathogen that produces them. Therefore we carriedout an epidemiological study of the gastroenteritis etiological agents and their incidencein the pediatric population. A total of 17 823 fecal samples were collected, 14 242 from HNJTuc,2,257 from CePSI-Stgo and 1,324 from HINEP-Cat. In 2,595 samples a bacterial agentwas identified, the 93.64% corresponded to Shigella/Salmonella clinical isolates. Shigellagenus was the prevalent pathogen, being Shigella flexneri 2 the most frequent serotype.Most of the Shigella clinical isolates presented themselves as multidrug-resistant (MDR),harboring 2 to 3 genetic resistance determinants. 50% of the affected patients were childrenunder 4 years old. Here, we demonstrate that bacterial gastrointestinal diseases stronglyaffect the health of NWA population. The appearance of epidemic outbreaks, as happenedduring 2014, suggest that they may be related to the socio-economic poverty of NWA.Recently, Shigella flexneri 2 has become the highest NWA´s incidence infectious agent.The acquisition of new antibiotic resistance determinants may play an important role in theiradaptation and persistence.