INVESTIGADORES
LOPEZ Fabian Enrique
artículos
Título:
Salmonella Typhimurium general virulence factors: a battle of David against Goliath?
Autor/es:
LOPEZ FABIAN E; PESCARETTI, M. M.; MORERO, R.D.; DELGADO, MONICA A.
Revista:
FOOD RESEARCH INTERNATIONAL
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Año: 2011
ISSN:
0963-9969
Resumen:
The genus Salmonella is the most common agent causative of
foodborne diseases. Although genus Salmonella members are genetically
close microorganisms, they show wide variations in host-specificity, virulence
and disease manifestations. Salmonellosis caused by contaminated water or food
is usually presents as two clinical forms: typhoid fever and nontyphoidal
diseases. The latter producing gastroenteritis is frequently caused by Salmonella
Typhimurium and Salmonella Enteritidis. The nontyphoidal S. Typhimurium
infection involves the following steps: bacterial adhesion, invasion, SCV
maturation and replication. During these steps there is a strong interaction
between host and pathogen, in which the pathogen must resist different host
defense mechanisms. In each of these stages the bacteria modulate the
expression of diverse groups of genes, most of which are encoded in Salmonella
pathogenicity islands (SPI). This modulation is in general under control of
the so-called two-component systems (TCS). The TCSs are capable of sensing
different environmental conditions and trigger a physiological response.
Currently, the risk of contracting salmonellosis disease has been considerably
increased due to the emergence of new serovars showing multiple-drugs
resistance that presents a high risk to human health. In this work, we
summarize the new advances in the study of host-pathogen interactions during
the Salmonella infection that leads to the establishment of the disease.
This finding highlights the role of the S. Typhimurium secretion systems
and effectors during infection. In addition, we mentioned some strategies that
could be explored in order to take control of Salmonella infections.