INVESTIGADORES
POLTI Marta Alejandra
artículos
Título:
Probiotic bacteria cell walls stimulate the activity of the intestinal epithelial cells and macrophage functionality
Autor/es:
LEMME-DUMIT, JOSÉ; POLTI, MARTA ALEJANDRA; PERDIGÓN, GABRIELA; MALDONADO GALDEANO, CAROLINA
Revista:
Beneficial Microbes
Editorial:
Wageningen Academic Publishers
Referencias:
Lugar: Wageningen; Año: 2018 vol. 9 p. 153 - 164
ISSN:
1876-2883
Resumen:
The effect of oral administration of probiotic bacteria cell walls (PBCWs) in the stimulation of the immune system in healthy BALB/c mice was evaluated. We focused our investigation mainly on intestinal epithelial cells (IECs) whichare essential for coordinating an adequate mucosal immune response and on the functionality of macrophages. The probiotic bacteria and their cell walls were able to stimulate the IECs exhibiting an important activation and cytokinereleases. Supplementation with PBCWs promoted macrophage activation from peritoneum and spleen, indicating that the PBCWs oral administration was able to improve the functionality of the macrophages. In addition, the PBCWs increased immunoglobulin A (IgA)-producing cells in the gut lamina propria in a similar way to probiotic bacteria, but this supplementation did not have an effect on the population of goblet cells in the small intestine epithelium. These results indicate that the probiotic bacteria and their cell walls have an important immunoregulatory effect on the IECs without altering the homeostatic environment but with an increase in IgA+ producing cells and in the innate immune cells,mainly those distant from the gut such as spleen and peritoneum. These findings about the capacity of the cell walls from probiotic bacteria to stimulate key cells, such as IECs and macrophages, and to improve the functioning of the immune system, suggest that those structures could be applied as a new oral adjuvant.