Pediatric glucose regulation without pre-meal insulin boluses: an approach based on switched control and time-varying IOB constraints

EMILIA FUSHIMI; HERNÁN DE BATTISTA; RICARDO SANCHEZ PEÑA; CECILIA SERAFINI; FABRICIO GARELLI

Berlin

Congreso; 21th World Congress of the International Federation of Automatic Control, IFAC-WC 2020; 2020

IFAC

Articial pancreas (AP) systems have shown to improve glucose regulation in type 1diabetes (T1D) patients. However, full closed-loop performance remains a challenge particularlyin children and adolescents, since these age groups often present the worst glycemic control. Inthis work, a new algorithm based on switched control and time-varying insulin-on-board (IOB)constraints is presented (ARGAE). This method is a combination of ideas from the previouslyintroduced Automatic Regulation of Glucose (ARG) algorithm, which features no pre-mealinsulin boluses, and the Amplitude Enable (AE) mode, which allows the controller to act moreaggressively at the beginning of meal intake without risking postprandial hypoglycemia. Theproposed control strategy is evaluated in silico and its performance contrasted with the ARGalgorithm in the pediatric population.