LEICI   25638
INSTITUTO DE INVESTIGACIONES EN ELECTRONICA, CONTROL Y PROCESAMIENTO DE SEÑALES
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Automatic Super-Bolus and Bolus-Shaping features for insulin pumps.
Autor/es:
HERNÁN DE BATTISTA; NICOLÁS ROSALES; FABRICIO GARELLI
Lugar:
Paris
Reunión:
Conferencia; 10th International Conference on Advanced Technologies & Treatments for Diabetes; 2017
Institución organizadora:
ATTD
Resumen:
Background and AimsThis work presents a method for automatic insulin bolus shaping based on residual insulin or insulin-on-board (IOB) estimation as an extra feature for commercial insulin pumps. Among other potential applications, this methodology allows the pump to automatically generate the so-called super-bolus for the compensation of high glycemic index meals, which has been recently related to the best theoretical basal-bolus combination for the reduction of glucose excursions under open-loop treatment [1].MethodThe method computes the individual extra amount of bolus and basal cutoff time from the duration of insulin action (DIA) of the patient using a physiological compartmental model for subcutaneous insulin absorption. Then, by means of a simple switching law, it automatically reestablishes basal insulin when IOB reaches its basal level, thus avoiding unnecessary detrimental transients generated with manual or a-priori computations.ResultsThe potential of this method, registered on patent and priority requests [2] and [3], are illustrated via in-silico trials in a realistic simulation platform based on the FDA-validated virtual patients which includes intra-patient variability and mixed meals. The results indicate that better performance is achieved with the same amount of administered insulin as the standard treatment. The table below shows the time in hyper and hypoglycemia reduction achieved with the proposed automatic SB with respect to standard treatment for a cohort of 30 patients facing a high glycemic index mixed meal of 25g, a mixed meal of 50g, and a 75g and 100g of CHO meal.