IDEAUS - CENPAT   25626
INSTITUTO DE DIVERSIDAD Y EVOLUCION AUSTRAL
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Fine-scale human genetic structure reveals Patagonian, Andean, and Gran-Chaco ancestry components throughout Argentina
Autor/es:
PIERRE LUISI; VIRGINIA RAMALLO; CONSORCIO POBLAR; JUAN MANUEL BERROS; HERNÁN DOPAZO
Lugar:
Viña del MAr
Reunión:
Congreso; 5to Congreso de la Sociedad Iberoamericana de Bioinformática; 2018
Institución organizadora:
Sociedad Iberoamericana de Bioinformática
Resumen:
Samples from South America in this metadataset exhibit a gradient of different proportions of native American vs. European ancestries, commonly observed in these kind of admixed populations. The African component is present in lesser proportion.In order to identify haplotypes of Native American ancestry, we phased theArgentinean and Chilean samples using shapeIT. We analysed 87 argentinians with Native American mtDNA, Affymetrix Axiom LAT 1 817K genetic markers was used.In contrast with the whole-genome (?unmasked?) PCA above, examining only the native portions of each genome with an ASPCA allowed us to find native population structure within the Argentinean genomes. Three native ancestries, here labeled the Gran-Chaco, the Central-Patagonic and the Andean, are found in varying proportions in different regions of Argentina. Individuals from the NEcluster closer to the Gran-Chaco populations, individuals from the NW cluster with Andean populations, individuals from the South cluster with native Chilean populations, and individuals from the Center of Argentina are found midway between the other groups.