CONICET | Buscador de Institutos y Recursos Humanos

EPIDERMAL GROWTH FACTOR RECEPTOR EXPRESSION IN SQUAMOUS CERVICAL CANCER AND ITS RELATION TO CHEMORADIOTHERAPYAyala NC; Miño A; Lorenzini MN; Alsina AE; Zimmermann, MCBackground and aims:Cervical Squamous Cell Carcinoma (CSCC) is a major cause of female mortality worldwide and a public health problem in Argentina. The molecular mechanism underlying radioresistance is still poorly understood. The epidermal growth factor receptor (EGFR), has been associated to poor survival. In the present study, we analyzed the correlation of EGFR expression and the clinical response to chemoradiotherapy.Methods:A retrospective study, including 115 patients was done between June 2013 and December 2017. Thirty six patients were eligible for weekly chemoradiotherapy cisplatin (40mg/m2) and brachytherapy. Efficacy of tumor response to treatment was performed by RECIST and gynecological examination. Immunohistochemically staining of EGFR was analyzed in primary biopsies. Stained hematoxylin and eosin slides where previously revised to confirm histological diagnostic. RT-PCR was performed amplifying a conserved region of EGFR genes, and its correlation of response to chemoradiotherapy was subsequently analyzed. Statistical analysis was assess using appropriate parametric and nonparametric tests.Results:EGFR expression, treatment received and clinical outcome were analyzed. The presence of measurable EGFR was found in all tumor samples. Patients with persistence tumor after chemoradiotherapy were found to have significantly higher median EGFR expression than those who had complete relapse of the tumor. Conclusion:We established a correlation between the expression of EGFR, before chemoradiotherapy, and the outcome of patients who conclude treatment. This potential pathway target may be valuable in the election of therapeutic options A more careful examination of experimental/clinical data may help to explain the mechanism(s) involving CSCC.