IQUIBA-NEA   25617
INSTITUTO DE QUIMICA BASICA Y APLICADA DEL NORDESTE ARGENTINO
Unidad Ejecutora - UE
artículos
Título:
Venoms and Isolated Toxins from Snakes of Medical Impact in the Northeast Argentina: State of the Art. Potential Pharmacological Applications
Autor/es:
GARCIA DENEGRI, MARÍA EMILIA; GAY, CLAUDIA CAROLINA; ECHEVERRÍA, SILVINA; VAN DE VELDE, ANDREA; BUSTILLO, SOLEDAD; NUÑEZ, SANDRA; GAUNA PEREIRA, MARÍA DEL CARMEN; GOMEZ, GABRIELA; TEIBLER, GLADYS PAMELA; MARUÑAK, SILVANA; BOGADO, FABIÁN; SANCHEZ, MATÍAS; FUSCO, LUCIANO; LEIVA, LAURA CRISTINA ANA
Revista:
Current Topics in Medicinal Chemistry
Editorial:
BENTHAM SCIENCE PUBL LTD
Referencias:
Lugar: Oak Park; Año: 2019 vol. 19 p. 1962 - 1980
ISSN:
1568-0266
Resumen:
Among the ophidians that inhabit the Northeast of Argentina, the genus Bothrops such as B. alternatus and B. diporus species (also known as yararás) and Crotalus durisus terrificus (named cascabel), represent the most studied snake venom for more than thirty years. These two genera of venomous snakes account for the majority of poisonous snake envenomations and therefore constitute a medical emergency in this region. This review presents a broad description of the compiled knowledge about venomous snakebite: its pathophysiological action, protein composition, isolated toxins, toxin synergism, toxin-antitoxin cross-reaction assays. Properties of some isolated toxins support a potential pharmacological application.