IQUIBA-NEA 25617
INSTITUTO DE QUIMICA BASICA Y APLICADA DEL NORDESTE ARGENTINO
Unidad Ejecutora - UE
artículos
Título:
Erythropoietin attenuates renal and pulmonary injury in polymicrobial induced-sepsis through EPO-R, VEGF and VEGF-R2 modulation
Autor/es:
DAIANA MARIA DE LOS ÁNGELES GARCÍA; JUAN SANTIAGO TODARO; DAIANA MARIA DE LOS ÁNGELES GARCÍA; JUAN SANTIAGO TODARO; TANIA ROMINA STOYANOFF; MARÍA VICTORIA AGUIRRE; TANIA ROMINA STOYANOFF; MARÍA VICTORIA AGUIRRE; MAURO HEITRICH; JUAN PABLO RODRÍGUEZ; MAURO HEITRICH; JUAN PABLO RODRÍGUEZ
Revista:
BIOMEDICINE & PHARMACOTHERAPY = BIOMEDECINE & PHARMACOTHERAPIE.
Editorial:
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
Referencias:
Año: 2016 p. 606 - 613
ISSN:
0753-3322
Resumen:
Sepsis remains the most important cause of acute kidney injury (AKI) and acute lung injury (ALI) in critically ill patients. The cecal ligation and puncture (CLP) model in experimental mice reproduces most of the clinical features of sepsis. Erythropoietin (EPO) is a well-known cytoprotective multifunctional hormone, which exerts anti-inflammatory, anti-oxidant, anti-apoptotic and pro-angiogenic effects in several tissues. The aim of this study was to evaluate the underlying mechanisms of EPO protection through the expression of the EPO/EPO receptor (EPO-R) and VEGF/VEF-R2 systems in kidneys and lungs of mice undergoing CLP-induced sepsis
