INCYT   25562
INSTITUTO DE NEUROCIENCIA COGNITIVA Y TRASLACIONAL
Unidad Ejecutora - UE
artículos
Título:
Dentate Gyrus Somatostatin Cells are Required for Contextual Discrimination During Episodic Memory Encoding
Autor/es:
FACUNDO MORICI, JUAN; LARA-VAZQUEZ, ARIEL; FUENTEALBA, PABLO; ESPINOSA, NELSON; BEKINSCHTEIN, PEDRO; MORALES, CRISTIAN; SACSON, AGOSTINA; WEISSTAUB, NOELIA V.
Revista:
CEREBRAL CORTEX
Editorial:
OXFORD UNIV PRESS INC
Referencias:
Lugar: Oxford; Año: 2020
ISSN:
1047-3211
Resumen:
Memory systems ought to store and discriminate representations of similar experiences in order to efficiently guide futuredecisions. This problem is solved by pattern separation, implemented in the dentate gyrus (DG) by granule cells to supportepisodic memory formation. Pattern separation is enabled by tonic inhibitory bombardment generated by multipleGABAergic cell populations that strictly maintain low activity levels in granule cells. Somatostatin-expressing cells are oneof those interneuron populations, selectively targeting the distal dendrites of granule cells, where cortical multimodalinformation reaches the DG. Nonetheless, somatostatin cells have very low connection probability and synaptic efficacywith both granule cells and other interneuron types. Hence, the role of somatostatin cells in DG circuitry, particularly in thecontext of pattern separation, remains uncertain. Here, by using optogenetic stimulation and behavioral tasks in mice, wedemonstrate that somatostatin cells are required for the acquisition of both contextual and spatial overlapping memories.