INCYT   25562
INSTITUTO DE NEUROCIENCIA COGNITIVA Y TRASLACIONAL
Unidad Ejecutora - UE
artículos
Título:
At the heart of neurological dimensionality
Autor/es:
FITTIPALDI, SOL; SANTAMARIA-GARCIA, HERNANDO; HILDEBRANDT, MALIN KATHARINA; MARTÍ, SOFÍA ALARCO; PAUTASSI, RICARDO MARCOS; IBÁÑEZ, AGUSTÍN; GARCÍA, ADOLFO M.; BIRBA, AGUSTINA; SALAMONE, PAULA; CORDERO, INDIRA GARCÍA; SERRANO, CECILIA; ABREVAYA, SOFÍA; DOTTORI, MARTIN; YORIS, ADRIÁN; DE LA FUENTE, ALETHEIA; CARO, MIGUEL MARTORELL; SEDEÑO, LUCAS; FITTIPALDI, SOL; SANTAMARIA-GARCIA, HERNANDO; HILDEBRANDT, MALIN KATHARINA; MARTÍ, SOFÍA ALARCO; PAUTASSI, RICARDO MARCOS; IBÁÑEZ, AGUSTÍN; GARCÍA, ADOLFO M.; BIRBA, AGUSTINA; SALAMONE, PAULA; CORDERO, INDIRA GARCÍA; SERRANO, CECILIA; ABREVAYA, SOFÍA; DOTTORI, MARTIN; YORIS, ADRIÁN; DE LA FUENTE, ALETHEIA; CARO, MIGUEL MARTORELL; SEDEÑO, LUCAS
Revista:
PSYCHOSOMATIC MEDICINE
Editorial:
LIPPINCOTT WILLIAMS & WILKINS
Referencias:
Lugar: Philadelphia; Año: 2020 vol. 82 p. 850 - 861
ISSN:
0033-3174
Resumen:
Objective: Neurological nosology, based on categorical systems, has largely ignored dimensional aspects of neurocognitive impairments. Transdiagnostic dimensional approaches of interoception (the sensing of visceral signals) may improve the descriptions of cross-pathological symptoms at behavioral, electrophysiological, and anatomical levels. Alterations of cardiac interoception (encompassing multidimensional variables such as accuracy, learning, sensibility, and awareness) and its neural correlates (electrophysiological markers, imaging-based anatomical and functional connectivity) have been proposed as critical across disparate neurological disorders. However, no study has examined the specific impact of neural (relative to autonomic) disturbances of cardiac interoception, or their differential manifestations across neurological conditions.Method: Here, we used a computational approach to classify and evaluate which markers of cardiac interoception (behavioral, metacognitive, electrophysiological, volumetric or functional) offer the best discrimination between neurological conditions and cardiac (hypertensive) disease (model 1); and among neurological conditions (Alzheimer´s disease, frontotemporal dementia, multiple sclerosis, and brain stroke; model 2). In total, the study comprised 52 neurological patients (mean ± SD age = 55.1 ± 17.3 years; 37 women); 25 cardiac patients (age = 66.2 ± 9.1 years; 13 women), and 72 healthy controls (age = 52.65 ± 17.1; 50 women).Results: Cardiac interoceptive outcomes successfully classified between neurological and cardiac conditions (model 1: > 80% accuracy), but not among neurological conditions (model 2: 53% accuracy). Behavioral cardiac interoceptive alterations, though present in all conditions, were powerful to differentiate between neurological and cardiac diseases. However, among neurological conditions, cardiac interoceptive deficits presented a more undifferentiated and unspecific disturbances across dimensions.Conclusions: Our result suggests a diffuse pattern of interoceptive alterations across neurological conditions, highlighting their potential role as dimensional, transdiagnostic markers.