INCYT   25562
INSTITUTO DE NEUROCIENCIA COGNITIVA Y TRASLACIONAL
Unidad Ejecutora - UE
artículos
Título:
Losing ground: Frontostriatal atrophy disrupts language embodiment in Parkinson’s and Huntington’s disease
Autor/es:
SEDEÑO, LUCAS; KOZONO, GISELLE; GARCÍA, ADOLFO M.; LEGAZ, AGUSTINA; BIRBA, AGUSTINA; IBÁÑEZ, AGUSTÍN; GARCÍA-CORDERO, INDIRA; SEDEÑO, LUCAS; GARCÍA, ADOLFO M.; KOZONO, GISELLE; LEGAZ, AGUSTINA; BIRBA, AGUSTINA; IBÁÑEZ, AGUSTÍN; GARCÍA-CORDERO, INDIRA
Revista:
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
Editorial:
PERGAMON-ELSEVIER SCIENCE LTD
Referencias:
Año: 2017 vol. 80 p. 673 - 687
ISSN:
0149-7634
Resumen:
Within the language domain, movement disorders triggered by frontostriatal damage are characterized by deficits in action verbs, motor-language coupling, and syntax. However, these impairments have not been jointly interpreted under a unifying rationale or integratively assessed in terms of possible clinical implications. To bridge these gaps, here we introduce the "disrupted motor grounding hypothesis", a new framework to conceive such impairments as disturbances of embodied mechanisms (high-order domains based on the recycling of functionally germane sensorimotor circuits). We focus on two relevant lesion models: Parkinson´s and Huntington´s disease. First, we describe the physiopathology of both conditions as models of progressive frontostriatal impairment. Then, we summarize works assessing action language, motor-language coupling, and syntax in samples at early and preclinical disease stages. To conclude, we discuss the implications of the evidence for neurolinguistic modeling, identify key issues to be addressed in future research, and discuss potential clinical implications. In brief, our work seeks to open new theoretical and translational avenues for embodied cognition research.