PERSONAL DE APOYO
OTTAVIANO Graciela Mabel
artículos
Título:
Beneficial Effect of Moderate Exercise in Kidney of Rat After Chronic Consumption of Cola Drinks
Autor/es:
CAO G; J GONZALES; MULLER A; OTTAVIANO G; AMBROSIO G; TOBLLI J; J MILEI
Revista:
PLOS ONE
Editorial:
PUBLIC LIBRARY SCIENCE
Referencias:
Lugar: San Francisco; Año: 2016 vol. 31 p. 1 - 1
ISSN:
1932-6203
Resumen:
AbstractAimThe purpose of this study was to investigate the effect of moderate intensity exercise on kidneyin an animal model of high consumption of cola soft drinks.MethodsForty-eight Wistar Kyoto rats (age: 16 weeks; weight: 350?400 g) were assigned to the followinggroups: WR (water runners) drank water and submitted to aerobic exercise; CR (colarunners) drank cola and submitted to aerobic exercise; WS (water sedentary) and CS (colasedentary), not exercised groups. The aerobic exercise was performed for 5 days per weekthroughout the study (24 weeks) and the exercise intensity was gradually increased duringthe first 8 weeks until it reached 20 meters / minute for 30 minutes. Body weight, lipid profile,glycemia, plasma creatinine levels, atherogenic index of plasma (AIP) and systolic bloodpressure (SBP) were determined. After 6 months all rats were sacrificed. A kidney histopathologicalscore was obtained using a semiquantitative scale. Glomerular size and glomerulosclerosiswere estimated by point-counting. The oxidative stress and proinflammatorystatus were explored by immunohistochemistry. A one way analysis of variance(ANOVA) with Tukey-Kramer post-hoc test or the Kruskal-Wallis test with Dunn?spost-hoc test was used for statistics. A value of p < 0.05 was considered significant.ResultsAt 6 months, an increased consumption of cola soft drink was shown in CS and CR comparedwith water consumers (p
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