IDECU   25222
INSTITUTO DE LAS CULTURAS
Unidad Ejecutora - UE
artículos
Título:
Oldest case of skeletal tuberculosis in Argentina: macroscopic, radiographic, molecular and lipid biomarker evidence in a male individual from Saujil (Catamarca).
Autor/es:
LEANDRO LUNA; HELEN DONOGHUE; GURDYAL SINGH BESRA; CHRISTOFER WILLIAMS; ARANDA, CLAUDIA; OONA YING-CHI LEE; DAVID MINNIKIN; NORMA RATTO; ANA SANTOS; HOUDINI HO TIN WU; GARETH LLEWELLYN
Revista:
Tuberculosis (Edinb)
Editorial:
CHURCHILL LIVINGSTONE
Referencias:
Lugar: ESCOCIA; Año: 2020 vol. 125 p. 101995 - 101995
ISSN:
1472-9792
Resumen:
The Mycobacterium tuberculosis complex (MTC) has affected South American populations since ca. 200 years BCE. In Argentina, possible cases date from ca. 1000?1400 Common Era (CE). This paper describes the oldest (905?1030 CE) confirmed case of tuberculosis (TB) in a young adult male from Lomitas de Saujil (Tinogasta, Catamarca, Argentina). Osteolytic lesions on the bodies of the lower spine were macroscopically and radiographically identified. Bilateral new bone formation was seen on the visceral vertebral third of several ribs and in long bones, compatible with hypertrophic osteoarthropathy. Representative rib and hand bones gave profiles for MTC-specific C27?C32 mycocerosic acid lipid biomarkers; these were strongest in one heavily-lesioned lower rib,which also had MTC-diagnostic C76?C89 mycolic acids and positive amplification of MTC-typical IS6110 aDNA fragments. During the first millennium CE, the intense social interaction, the spatial circumscription of villages among the pre-Hispanic societies in the mesothermal valleys of Catamarca and the fluid contacts with the Eastern lowlands, valleys and puna, were factors likely to favor disease transmission. It is proposed that TB arrived from northern Chile and dispersed towards the northeast into the Yocavil valley, where several cases of TB infection were macroscopically identified for a later chronology.