EVALUATION OF PROS1, GAS6 AND TAM RECEPTORS EXPRESSION IN DUODENAL MUCOSAE OF CELIAC DISEASE PATIENTS

RUERA, CAROLINA; CARASI PAULA; CHIRDO, FERNANDO; PEREZ, FEDERICO; GOMEZ CASTRO, MARÍA FLORENCIA; CARRERA SILVA, EUGENIO ANTONIO ; MICULAN, EMANUEL; GUZMAN, LUCIANA

Mar del Plata

Congreso; SAIC-SAI-SAFE 2018; 2018

SAIC-SAI-SAFE

The tyrosine kinase Tyro-3, Axl and Mertk (TAM) receptors and their endogenous ligands Protein S (Pros1) and the Growth arrest-specific factor 6 (Gas6) have been shown to play an essential role in hemostasis, removal of apoptotic bodies, control of the inflammatory response as well as in the pathogenesis of different diseases. Scarce information regarding this axis and small intestine has been reported. We are interested in studying the TAM axis in human small intestine under physiological and pathological conditions, such as in Celiac disease (CD). CD is a chronic enteropathy characterized by epithelial cell death, loss of villus structure as well as others histological changes as consequence of an uncontrolled Th1 response specific for wheat proteins.