Could probióticos be proposed as an optional treatment for IBD?

CANZIANI, K.; ERREA, A; ROCCA, A; YANTORNO, M; DOCENA, G.; CURCIARELLO, R; SERRADELL, M; HUGO, A; SAMBUELLI, A.; GARBI, L; SALTO, I; RUMBO, M; BRAYER, S; CORREA G; MUGLIA C.I.

Mar del Plata

Congreso; SAI-SAIC-SAFIS 2018; 2018

Inflammatory bowel diseases (IBD) are a group of disorders, including the most conspicuous ones ulcerative colitis (UC) and Crohn´s disease (CD), which are characterized by chronic inflammation of the gastrointestinal tract. Affected Individuals suffer from debilitating symptoms with severe complications, and a higher risk of colorectal cancer. The frequency of IBD is increasing worldwide, seriously affecting health care costs and inbreeding hospital beds. Over the last decades great effort has been dedicated to understand these pathologies. It is well known that mucosal T cells (LPTC) play a central role in these pathologies, by secreting pro-inflammatory cytokines, having impaired apoptosis. Although new therapies have arisen, among them anti-TNF humanized antibodies, there is no therapy that works for all patients. What is more, some patients initially responsive to anti-TNF therapy, acquire resistance later. It is for this reason that the search for new therapeutical strategies is needed. Kefir is a fermented milk with health-promoting properties that has been used for gastrointestinal disorders treatment since ancient times. In our group we have established a method for developing antigen-specific T cell lines from lamina propria of mucosal samples from IBD patients. We show that microorganisms from kefir (Enterococcus durans and Lactobacillus kefiri) or their conditioned media modulate anti-CD3/anti-CD28 induced proliferation and the secretion of pro-inflammatory cytokines by LPTCs. Also, these probiotics decreased NFKB activation in these cellsAltogether, probiotic strains from kefir and their metabolites can modulate pathogen-specific activated T cells from IBD patients, leading to new venues for future therapeutic approaches for IBD.