Oxidovanadium(IV) complexes with flavonoids. Anticancer activity and mechanisms of action in a human colon adenocarcinomamodel: role of activation of nfkband apoptosis

LEÓN I.; MUGLIA C.I.; PORRO, V.; TISCORNIA I.; BOLLATI-FOGOLIN, M.; ETCHEVERRY, S.

Durham NC

Simposio; 9th International Biometals Symposium; 2014

The family of polyphenolic flavonoids presents anti-inflammatory and anti-tumor effects. In particular, Chrysin and Silibinin are interesting members of this family, with potent anti-proliferative and anti-metastatic effects against various malignant cell lines. Oxidovanadium(IV) complexes show interesting pharmacological activity mainly as insulin enhancers, osteogenic and anti-tumor agents. In this work we report the biological effects of two complexes of vanadyl(IV) with Chrysin and Silibinin on a human colon adenocarcinoma cell line (HT-29 ATCC HTB 38). VOsil caused an inhibitory effect on cell viability in the range of 75-100 μM while VOchrys only provoked this effect at 100 μM (p