The pro-apoptotic galectin-1 is functionally inhibited in inflamed intestinal areas of IBD patients

ROCCA, A; SAMBUELLI, A.; RABINOVICH, G.; TOSCANO, M.; GIL, A; NEGREIRA, S; HUERNOS, S; GONCALVES, S; BELLICOSO, M; TIRADO, P; CURCIARELLO, R; IRIGOYEN, A; MUGLIA C.I.; YANTORNO, M; DOCENA, G.; PAPA GOBBI, R

Compenhaue

Conferencia; IX Congress of ECCO; 2014

Galectins (Gal) are glycan-binding proteins that have been implicated in several pathologic and physiologic processes. It has been described key roles in the regulation of the immune system. Inflammatory bowl diseases (IBD) are a group inflammatory disorders that mainly affect the gastrointestinal tract and constitute a chronic and relapsing condition. IBD are characterized by two forms of intestinal inflammation: Crohn´s disease (CD) and ulcerative colitis (UC). It has been accepted that the mucosal immune dysfunction is central in the pathogenesis, and thet T cells are mainly implicated. The aim of this study was to analyze the role of Gal-1 in this inflammatory setting, that mainly affects the colon of patients with UC and CD.