Characterization of age-related differences in impulsivity among adolescent and adult rats

DÍAZ, SOFIA; KATCHE, CYNTHIA; MARINI, MICAELA BETSABÉ; MARTÍNEZ, MARÍA CECILIA

Congreso; XXXV Congreso Anual Sociedad Argentina de Investigación en Neurociencias; 2020

Adolescence is a developmentalperiod in which many behavioral and physiological changes occur,preparing individuals for their independence. There are age-relatedincreases in social interactions and a also a clear preference forrisk-taking/novelty seeking behaviors. Consistently with this, infreely-moving experiments ina self-initiated taskwe have found a higher amount of premature responses in adolescentrats. Thus, the aim of this project is to fully characterize howadolescents and adults learn an action sequence in order to obtain areward and also to find which aspects of adolescent behavior could beat the basis of the impulsivity we have previously observed in thistask. We will train p30, p 45 and p60 rats of both sexes and evaluatetheir performance in other paradigms such as the open field andY-maze. Here we show the results obtained with the first group ofadults. In a next stage, after the behavioral analysis is complete,we will assess the involvement of different brain structures withpharmacological inactivation.p { margin-bottom: 0.1in; direction: ltr; color: #000000; line-height: 120%; orphans: 2; widows: 2 }p.western { font-family: "Liberation Serif", "Times New Roman", serif; font-size: 12pt; so-language: en-US }p.cjk { font-family: "Noto Sans CJK SC Regular"; font-size: 12pt; so-language: zh-CN }p.ctl { font-family: "FreeSans"; font-size: 12pt; so-language: hi-IN }