IFIBIO HOUSSAY   25014
INSTITUTO DE FISIOLOGIA Y BIOFISICA BERNARDO HOUSSAY
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Unsupervised cluster analysis of task solving strategies using an animal model of striatal cholinergic interneurons ablation
Autor/es:
MURER MG; BECCARIA JP; BELFORTE, J.E.
Lugar:
carlos paz
Reunión:
Congreso; Reunion Anual de la Sociedad Argentina de Investigación en Neurociencias (SAN); 2019
Institución organizadora:
Sociedad Argentina de Investigación en Neurociencias (SAN)
Resumen:
Goal directed tasks (GDT) entail animals behaving according to experimental designs in order to receive areward or avoid punishment. Many times, however, animals solve mazes through a variety of differentindividual strategies that may not have been foreseen by the experimenter. We have previously shown thatstriatal cholinergic interneurons (SCIN) are required to establish solving strategies in spatial navigation tasks.Moreover, our previous results suggest SCIN deletion induces a performance improvement in GDT. Nonetheless,the role of SCIN in other GDT strategies has not been assessed yet. To determine whether SCIN-associatedenhancement is explained by a strategy-related change, we conducted an unbiased multivariable analysis ofanimals´ behavior after subjecting control and SCIN ablated mice to a two-alternative free choice operantconditioning task. For that, we studied 19 behavioral variables and used them in an unsupervised clusteranalysis. We found that control group was formed by two behavioral clusters that displayed two differentstrategies. Conversely, lesioned mice constituted a less variable group strongly enriched in a single strategy.These results suggest that: 1) limited behavioral constrains in a GDT could lead to different, but equallyeffective, solving strategies in control mice. 2) Better performance of lesioned group may be due to a limitedcompetence between strategies, 3) SCIN role in strategy selection may not be limited to navigational tasks.