Impacto de tiempos de bomba prolongados y cambios en la osmolaridad plasmática sobre eventos cardiovasculares a dos años: una cohorte prospectiva

VIRGINIA BARBA; RAÚL FERREYRA; GUSTAVO SALVO; CLAUDIA CAPURRO; GUILLERMO BORTMAN; MARIA TERESA POLITI; FACUNDO SERAFICA; ANTONIO PIAZZA

Congreso; 45 Congreso de Sociedad Argentina de Cardiología; 2019

Introduction: The objective of this study is to evaluate whether prolonged on-pump times and changes in plasma osmolarity during cardiovascular surgeries with cardiopulmonary bypass are associated with mortality and cardiovascular events in the two years following surgery.Methods: This is a prospective single-center cohort study that included patients undergoing cardiovascular surgery with cardiopulmonary bypass, followed for two years by telephone communication. Those with incomplete data regarding main predictor variables were excluded. Predictor variables were prolonged on-pump times (≥ 80 minutes) and changes in plasma osmolarity calculated between pre and postoperative values. The outcomes were two-year mortality and the combined event of two-year mortality, re-hospitalization or re-surgery.Results: 115 patients underwent cardiovascular surgery with cardiopulmonary bypass. The two-year follow-up was 84% of the initial population. Prolonged on-pump times showed a significant association with two-year cardiovascular events (OR = 2.43; p = 0.040), but not with two-year mortality (OR = 3.83; p = 0.053). Similarly, 10 mOsm changes in calculated plasma osmolarity were associated with two-year cardiovascular events (OR = 2.11; p = 0.005), but not with two-year mortality (OR = 1.33; p = 0.305 ). All results are reported adjusted to the EuroScore II.Conclusions: Prolonged on-pump times and subsequent changes in plasma osmolarity could have a long-term clinical impact.