IFIBIO HOUSSAY   25014
INSTITUTO DE FISIOLOGIA Y BIOFISICA BERNARDO HOUSSAY
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Role of the lateral habenula in a rewarded contextual dependent task
Autor/es:
SABASTIAN MARTINEZ; JOAQUIN PIRIZ; FRANCO CHIESA DOCAMPO; MARIANO BELLUSCIO; VERÓNICA DE LA FUENTE; RICARDO SÁNCHEZ PEÑA
Lugar:
Córdoba
Reunión:
Congreso; XXXIII CONGRESO ANUAL SAN 2018; 2018
Institución organizadora:
Sociedad Argentina de Investigación en Neurociencias
Resumen:
The lateral habénula (LHb) is a diencephalic nucleus that plays critical functions in cognitive process. Increased activity of LHb neurons correlates with aversive stimuli presentation, whereas stimulation of LHb promotes avoidance behaviors. Concordantly, LHb projects to areas that control motivation, such as the ventral tegmental area and the rostromedial tegmental nucleus. Rewards, either negative or positive, are always given in a context. Increasing evidence supports a functional relation between the the LHb and the hippocampus, a brain structure relevant for coding contextual information. In this scenario, our main goal is to study how the LHb processes information, and ultimately, how it functionally interacts with the hippocampus when animals perform a rewarded contextual dependent task. We implemented an arduino/Bonsai based system to analyze the behavior of rats as they look for a reward in our heart shaped-maze task. This system allow us to optogenetically stimulate in a specific part of the maze. . Our preliminary results indicate that stimulation of the LHb makes the animal avoid the place where stimulation has occurred, either evaluated in a real time preference task or in our maze.