Study of megalin expression and determination of podocyturia in preeclamptic pregnant woman as an early marker of kidney damage

OCHOA, F; LAGO, N; COSTALES, C; DIAZ, A; ZOTTA, E; SEYAHIAN, A; IARIA, A

Congreso; LXIII Reunión Anual de la Sociedad Argentina de Investigación Clínica (SAIC); 2018

􀀳􀁕􀁈􀁈􀁆􀁏􀁄􀁐􀁓􀁖􀁌􀁄􀀃 􀁌􀁖􀀃 􀁄􀀃 􀁋􀁜􀁓􀁈􀁕􀁗􀁈􀁑􀁖􀁌􀁙􀁈􀀃 􀁇􀁌􀁖􀁒􀁕􀁇􀁈􀁕􀀃 􀁚􀁌􀁗􀁋􀀃 􀁐􀁘􀁏􀁗􀁌􀁖􀁜􀁖􀁗􀁈􀁐􀀃 􀁌􀁑􀁙􀁒􀁏􀁙􀁈-􀁐􀁈􀁑􀁗􀀃 􀁌􀁑􀀃 􀁓􀁕􀁈􀁊􀁑􀁄􀁑􀁗􀀃 􀁚􀁒􀁐􀁈􀁑􀀃 􀁚􀁌􀁗􀁋􀀃 􀁐􀁒􀁕􀁈􀀃 􀁗􀁋􀁄􀁑􀀃 􀀕􀀓􀀃 􀁚􀁈􀁈􀁎􀁖􀀃 􀁒􀁉􀀃 􀁊􀁈􀁖􀁗􀁄􀁗􀁌􀁒􀁑􀁄􀁏􀀃􀁄􀁊􀁈􀀏􀀃􀁒􀁉􀀃􀁘􀁑􀁎􀁑􀁒􀁚􀁑􀀃􀁆􀁄􀁘􀁖􀁈􀀑􀀃􀀬􀁗􀀃􀁌􀁖􀀃􀁆􀁋􀁄􀁕􀁄􀁆􀁗􀁈􀁕􀁌􀁝􀁈􀁇􀀃􀁅􀁜􀀃􀁄􀁑􀁒􀁐􀁄􀁏􀁒􀁘􀁖􀀃􀁓􀁏􀁄􀁆􀁈􀁑􀁗􀁄-􀁗􀁌􀁒􀁑􀀏􀀃􀁚􀁌􀁗􀁋􀀃􀁓􀁕􀁈􀁖􀁈􀁑􀁆􀁈􀀃􀁒􀁉􀀃􀁋􀁜􀁓􀁒􀁛􀁌􀁄􀀒􀀃􀁌􀁖􀁆􀁋􀁈􀁐􀁌􀁄􀀃􀁓􀁏􀁄􀁆􀁈􀁑􀁗􀁄􀁏􀀏􀀃􀁇􀁜􀁖􀁉􀁘􀁑􀁆􀁗􀁌􀁒􀁑􀀃􀁒􀁉􀀃􀁗􀁋􀁈􀀃􀁐􀁄􀁗􀁈􀁕􀁑􀁄􀁏􀀃􀁈􀁑􀁇􀁒􀁗􀁋􀁈􀁏􀁌􀁘􀁐􀀏􀀃􀁌􀁐􀁅􀁄􀁏􀁄􀁑􀁆􀁈􀀃􀁅􀁈􀁗􀁚􀁈􀁈􀁑􀀃􀁓􀁕􀁒􀀃􀁄􀁑􀁇􀀃􀁄􀁑􀁗􀁌􀀃􀁄􀁑􀁊􀁌􀁒􀁊􀁈􀁑􀁌􀁆􀀃􀁉􀁄􀁆􀁗􀁒􀁕􀁖􀀃􀁄􀁑􀁇􀀃􀁐􀁄􀁕􀁎􀁈􀁇􀀃􀁈􀁛􀁓􀁕􀁈􀁖􀁖􀁌􀁒􀁑􀀃􀁒􀁉􀀃􀁓􀁕􀁒􀁌􀁑􀃁􀁄􀁐􀁐􀁄􀁗􀁒􀁕􀁜􀀃􀁆􀁜􀁗􀁒􀁎􀁌􀁑􀁈􀁖􀀑􀀃􀀺􀁌􀁗􀁋􀁌􀁑􀀃the clinical manifestations of renal involvement, it can be associated􀁚􀁌􀁗􀁋􀀃 􀁗􀁋􀁈􀀃 􀁓􀁕􀁈􀁖􀁈􀁑􀁆􀁈􀀃 􀁒􀁉􀀃 􀁓􀁕􀁒􀁗􀁈􀁌􀁑􀁘􀁕􀁌􀁄􀀃 􀁗􀁒􀁊􀁈􀁗􀁋􀁈􀁕􀀃 􀁚􀁌􀁗􀁋􀀃 􀁈􀁏􀁈􀁙􀁄􀁗􀁈􀁇􀀃 􀁆􀁕􀁈􀁄􀁗􀁌􀁑􀁌􀁑􀁈􀀃􀁏􀁈􀁙􀁈􀁏􀁖􀀑􀀃 􀀧􀁘􀁕􀁌􀁑􀁊􀀃 􀁊􀁏􀁒􀁐􀁈􀁕􀁘􀁏􀁄􀁕􀀃 􀁌􀁑􀁍􀁘􀁕􀁜􀀏􀀃 􀁓􀁒􀁇􀁒􀁆􀁜􀁗􀁈􀁖􀀃 􀁆􀁄􀁑􀀃 􀁇􀁈􀁗􀁄􀁆􀁋􀀃 􀁉􀁕􀁒􀁐􀀃 􀁗􀁋􀁈􀀃􀁅􀁄􀁖􀁈􀁐􀁈􀁑􀁗􀀃􀁐􀁈􀁐􀁅􀁕􀁄􀁑􀁈􀀏􀀃􀁄􀁖􀀃􀁚􀁈􀁏􀁏􀀃􀁄􀁖􀀃􀁄􀁏􀁗􀁈􀁕􀀃􀁗􀁋􀁈􀀃􀁈􀁑􀁇􀁒􀁆􀁜􀁗􀁒􀁖􀁌􀁖􀀃􀁐􀁈􀁆􀁋􀁄􀁑􀁌􀁖􀁐􀀃of proximal tubule proteins. The pathophysiological mechanisms of􀁓􀁕􀁈􀁈􀁆􀁏􀁄􀁐􀁓􀁖􀁌􀁄􀀃􀁄􀁑􀁇􀀃􀁕􀁈􀁑􀁄􀁏􀀃􀁌􀁑􀁙􀁒􀁏􀁙􀁈􀁐􀁈􀁑􀁗􀀃􀁄􀁕􀁈􀀃􀁖􀁗􀁌􀁏􀁏􀀃􀁘􀁑􀁎􀁑􀁒􀁚􀁑􀀑􀀲􀁘􀁕􀀃􀁒􀁅􀁍􀁈􀁆􀁗􀁌􀁙􀁈􀀃􀁚􀁄􀁖􀀃􀁗􀁒􀀃􀁇􀁈􀁗􀁈􀁕􀁐􀁌􀁑􀁈􀀃􀁗􀁋􀁈􀀃􀁓􀁒􀁇􀁒􀁆􀁌􀁗􀁘􀁕􀁌􀁄􀀃􀁌􀁑􀀃􀁑􀁒􀁕􀁐􀁄􀁏􀀃􀁄􀁑􀁇􀀃􀁓􀁕􀁈-􀁈􀁆􀁏􀁄􀁐􀁓􀁗􀁌􀁆􀀃 􀁓􀁕􀁈􀁊􀁑􀁄􀁑􀁗􀁖􀀃 􀁄􀁑􀁇􀀃 􀁗􀁒􀀃 􀁆􀁒􀁕􀁕􀁈􀁏􀁄􀁗􀁈􀀃 􀁗􀁋􀁈􀀃 􀁕􀁈􀁖􀁘􀁏􀁗􀁖􀀃 􀁚􀁌􀁗􀁋􀀃 􀁗􀁋􀁈􀀃 􀁇􀁈􀁙􀁈􀁏􀁒􀁓-ment of proteinuria.􀀃 􀀸􀁕􀁌􀁑􀁈􀀃 􀁖􀁄􀁐􀁓􀁏􀁈􀁖􀀃 􀁉􀁕􀁒􀁐􀀃 􀁓􀁕􀁈􀁊􀁑􀁄􀁑􀁗􀀃 􀁚􀁒􀁐􀁈􀁑􀀃 􀁒􀁉􀀃 􀁗􀁋􀁈􀀃 􀀩􀁈􀁕􀁑􀁩􀁑􀁇􀁈􀁝􀀃 􀀫􀁒􀁖􀁓􀁌􀁗􀁄􀁏􀀃􀁚􀁈􀁕􀁈􀀃􀁘􀁖􀁈􀁇􀀃􀁅􀁈􀁉􀁒􀁕􀁈􀀃􀁄􀁑􀁇􀀃􀁄􀁉􀁗􀁈􀁕􀀃􀀕􀀓􀀃􀁚􀁈􀁈􀁎􀁖􀀃􀁒􀁉􀀃􀁊􀁈􀁖􀁗􀁄􀁗􀁌􀁒􀁑􀀃􀁄􀁑􀁇􀀃􀁓􀁕􀁈􀁈􀁆􀁏􀁄􀁐􀁓􀁗􀁌􀁆􀀃􀁕􀁈􀁑􀁄􀁏􀀃􀁅􀁌􀁒􀁓􀁖􀁜􀀃􀁗􀁌􀁖􀁖􀁘􀁈􀀃􀁉􀁕􀁒􀁐􀀃􀀦􀀨􀀳􀀨􀀤􀀃􀁅􀁈􀁗􀁚􀁈􀁈􀁑􀀃􀀔􀀜􀀚􀀓􀀃􀁄􀁑􀁇􀀃􀀔􀀜􀀛􀀓􀀑􀀃 􀀬􀁑􀁇􀁌􀁕􀁈􀁆􀁗􀀃 􀁌􀁐􀁐􀁘􀁑􀁒􀃁􀁘􀁒􀁕􀁈􀁖􀁆􀁈􀁑􀁆􀁈􀀃 􀁚􀁄􀁖􀀃 􀁓􀁈􀁕􀁉􀁒􀁕􀁐􀁈􀁇􀀃 􀁉􀁒􀁕􀀃 􀁖􀁜􀁑􀁄􀁓􀁗􀁒􀁓􀁒􀁇􀁌􀁑􀀃(1/100) and the expression of megalin (1/100) in histological sam-􀁓􀁏􀁈􀁖􀀃􀁚􀁄􀁖􀀃􀁖􀁗􀁘􀁇􀁌􀁈􀁇􀀑􀀃􀀺􀁈􀀃􀁆􀁄􀁕􀁕􀁜􀀃􀁒􀁘􀁗􀀃􀁗􀁋􀁈􀀃􀁄􀁖􀁖􀁒􀁆􀁌􀁄􀁗􀁌􀁒􀁑􀀃􀁒􀁉􀀃􀁗􀁋􀁈􀀃􀃀􀁑􀁇􀁌􀁑􀁊􀁖􀀃􀁚􀁌􀁗􀁋􀀃the clinical data of the patients, relating it to the presence of proteinuria.􀀲􀁘􀁕􀀃 􀁕􀁈􀁖􀁘􀁏􀁗􀁖􀀃 􀁖􀁋􀁒􀁚􀁈􀁇􀀃 􀁄􀁑􀀃 􀁌􀁑􀁆􀁕􀁈􀁄􀁖􀁈􀀃 􀁌􀁑􀀃 􀁓􀁒􀁇􀁒􀁆􀁜􀁗􀁘􀁕􀁌􀁄􀀃 􀁄􀁖􀀃 􀁗􀁋􀁈􀀃 􀁊􀁈􀁖􀁗􀁄􀁗􀁌􀁒􀁑􀁄􀁏􀀃􀁄􀁊􀁈􀀃􀁓􀁕􀁒􀁊􀁕􀁈􀁖􀁖􀁈􀁇􀀃􀁌􀁑􀀃􀁗􀁋􀁈􀀃􀁓􀁄􀁗􀁌􀁈􀁑􀁗􀁖􀀃􀁚􀁋􀁒􀀃􀁇􀁈􀁙􀁈􀁏􀁒􀁓􀁈􀁇􀀃􀁓􀁕􀁈􀁈􀁆􀁏􀁄􀁐􀁓􀁖􀁌􀁄􀀃􀁅􀁈􀁉􀁒􀁕􀁈􀀃the presence of proteinuria, being more representative at gestation-􀁄􀁏􀀃􀁄􀁊􀁈􀁖􀀡􀀃􀀖􀀓􀀃􀁚􀁈􀁈􀁎􀁖􀀑In renal biopsies, megalin expression decreased in membrane andcytoplasm of proximal tubules.􀀷􀁋􀁈􀀃􀁌􀁑􀁆􀁕􀁈􀁄􀁖􀁈􀀃􀁌􀁑􀀃􀁓􀁒􀁇􀁒􀁆􀁜􀁗􀁘􀁕􀁌􀁄􀀃􀁚􀁌􀁗􀁋􀀃􀁊􀁈􀁖􀁗􀁄􀁗􀁌􀁒􀁑􀁄􀁏􀀃􀁄􀁊􀁈􀀃􀁌􀁑􀀃􀁗􀁋􀁈􀁖􀁈􀀃􀁓􀁄􀁗􀁌􀁈􀁑􀁗􀁖􀀃could be an early marker of kidney involvement compared to proteinuria.The diminished expression of megalin at the tubular level in renalbiopsies demonstrates the involvement of tubular damage in thegenesis of proteinuria during preeclampsia.