IFIBIO HOUSSAY   25014
INSTITUTO DE FISIOLOGIA Y BIOFISICA BERNARDO HOUSSAY
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
URIC ACID LEVELS IN GESTATIONS COMPLICATED WITH PREECLAMPSIA AND FETAL GROWTH RESTRICTION
Autor/es:
ORTIZ, MARIA; DAMIANO, ALICIA E; COROMINAS ANA; MASKIN BERNARDO; BALCONI SILVIA; MARTINEZ, NORA
Reunión:
Congreso; Reunión Anual de la Sociedad Argentina de Investigaciones Clínicas.; 2018
Resumen:
Preeclampsia is a pregnancy disorder characterized by the onset of hypertension after 20 weeks of gestation. Although its etiology is unknown, inadequate placentation and maternal vascular dysfunction were associated with multiple complications and increased maternal and fetal morbimortality. Preeclampsia is subdivided into early (before 34+0 weeks) and late(after 34+0 weeks) onset, with or without intrauterine fetal growth restriction (IUGR).The identification of pregnant women at risk for preeclampsia is still difficult and current biomarkers fail to differentiate preeclampsia associated to IUGR with pure IUGR without preeclampsia.In other tissues, it was reported that an increase in serum uric acid may be related to endothelial dysfunction. Previously, we demonstrated that uricemia increased in preeclamptic pregnancies, and the uricemia ratio after and before the 20th week of gestation may be useful to discard those women who are not at risk of developing preeclampsia.Our aim was to evaluate the behavior of the uricemia ratio in pregnancies complicated by IUGR associated or not to preeclampsia.A retrospective descriptive-quantitative study was carried out in all women who attended their pregnancy at the Hospital Posadas during 2014. Uricemia ratio (uricemia after 20th week /uricemia before 20th week) was calculated in women who presented IUGR in simple pregnancies associated or not to preeclampsia. In 3794 simple gestations analyzed, 214 presented IUGR. In gestations complicated with preeclampsia associated to IUGR 58% of the newborns were under percentile 3, whereas in pregnancies with pure IUGR without preeclampsia, only 33% of the newborns were under percentile 3. Uricemia ratios were higher in women with preeclampsia and IUGR than in those who only presented IUGR (2.03±0.67 vs 1.23±0.30, p