IFIBIO HOUSSAY   25014
INSTITUTO DE FISIOLOGIA Y BIOFISICA BERNARDO HOUSSAY
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Unbalanced corticostriatal connectivity in a mouse model of neonatal dopamine dysfunction
Autor/es:
BRAZ B ; MURER MG ; BELFORTE JE
Lugar:
Bordeaux
Reunión:
Congreso; Neurfrance 2017; 2017
Institución organizadora:
Societe Francaise des Neurosciences.
Resumen:
Early postnatal disturbances of forebrain dopamine (DA) neurotransmission are relevant to our understanding of some neuropsychiatricdisorders with a developmental component, like the attention deficit hyperactivity disorder (ADHD). Patients with ADHD show depressed DAactivity in the caudate nucleus, delayed maturation of caudate volume, and often respond to DA neurotransmission enhancing drugs.Findings in rodents showing that neonatal lesions of the forebrain dopaminergic system induced by the neurotoxin 6-hydroxydopamine (6-OHDA) lead to juvenile locomotor hyperactivity and learning deficits have been taken as evidence of face validity for ADHD.In a previous study (Braz et al. 2015, see below) we found that neonatal DA depletion results in exacerbated local exploration, deficits inforaging for information and failure to exploit shelter, nutritional and social resources (1). These behavioral changes are accompanied by areduction in prefrontostriatal functional connectivity (1) and a contraction of medium spiny neuron (MSN) dendritic arbor (3).Despite the important role of DA in maintaining the activity balance between the direct and indirect pathways, little is known about thedevelopmental involvement of dopamine in this process.