IFIBIO HOUSSAY   25014
INSTITUTO DE FISIOLOGIA Y BIOFISICA BERNARDO HOUSSAY
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Dopamine differentially shapes the excitability and connectivity of direct and indirect pathway medium spiny neurons during postnatal development
Autor/es:
MURER, MG; GIUGOVAZ, B; BRAZ, BY; RELA, L; KEIFMAN, E; BELFORTE, JE; PAZ, R
Lugar:
Rungstedgaard
Reunión:
Conferencia; Spring Brain Conference 2018; 2018
Institución organizadora:
Federation of European Neuroscience Societies
Resumen:
Early postnatal disturbances of forebrain dopamine (DA) neurotransmission are relevant to our understanding of some neuropsychiatric disorders with a developmental component, like the attention deficithyperactivity disorder (ADHD). Patients with ADHD show depressed DA activity in the caudate nucleus, delayed maturation of caudate volume, and often respond to DA neurotransmission enhancing drugs.Findings in rodents showing that neonatal lesions of the forebrain dopaminergic system induced by the neurotoxin 6-hydroxydopamine (6-OHDA) lead to juvenile locomotor hyperactivity and learning deficits havebeen taken as evidence of face validity for ADHD. In a previous study (Braz et al. 2015) we found that neonatal DAdepletion results in exacerbated local exploration, deficits in foraging for information and failure toexploit shelter, nutritional and social resources. These behavioral changes are accompanied by a reduction in prefrontostriatal functional connectivity and a contraction of medium spiny neuron (MSN) dendriticarbor. Despite the important role of DAin maintaining the activity balance between the direct and indirect pathways, little is known about the developmental involvement of dopamine in this process.Here, we ask whether the neonatal dopamine lesion differentially affects the excitability and functional connectivity of the direct and indirect medium spiny neurons (dMSN and iMSN, respectively)