New insights into the role of AQP1 in the genesis of Polyuria during diabetes mellitus?.

ZOTTA ELSA; OCHOA FEDERICO, ; LAGO NÉSTOR, ; SEYAHIAN, E. ABRIL,; CACCIAGIU LEONARDO, ; DAMIANO ALICIA E, ; COSTALES CRISTIAN,

Congreso; IV International Congress in Translational Medicine; 2018

Diabetes constitutes a group of metabolic diseases characterized by hyperglycaemia as a result of defective insulin secretion, insulin action or a combination of both factors. Its classic symptoms polydipsia, polyuria, polyphagia and loss of body weight. Until now, the genesis of polyuria has been considered an osmotic effect, resulting from glucose remaining in the tubule. Glucose filters freely through the glomerular filtration barrier and is later reabsorbed in the proximal tubule by two transporters: SGLT1 and SGLT2. During diabetes there is an increase in the filtered glucose load, transporters get saturated, and glucose remains in the tubular fluid, exerting an osmotic effect which prevents glucose reabsorption.Aquaporin 1 (AQP1) is a water channel strongly expressed in the proximal tubule, where 70% of filtered water is reabsorbed. It has an hypertonicity response element. Although AQP1 protein mediates water reabsorption, and polyuria is a hallmark of diabetes, its role in the genesis of said polyuria has never been studied.