IFIBIO HOUSSAY   25014
INSTITUTO DE FISIOLOGIA Y BIOFISICA BERNARDO HOUSSAY
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
HYPOTHALAMIC POMC PROTECTS AGAINST GLUCOSE INTOLERANCE BY IMPROVING INSULIN SENSITIVITY
Autor/es:
TROTTA MILAGROS; ALSINA RAMIRO; BUMASCHNY VIVIANA
Lugar:
BUENOS AIRES
Reunión:
Congreso; Reunión Conjunta de Sociedades de Biociencias (LXII Reunión anual de la Sociedad Argentina de Investigación Clínica, SAIC); 2017
Resumen:
Elucidating the central nervous system mechanisms that participatein the control of glucose homeostasis could lead to newtherapies for diabetes. The hypothalamus is a main regulator ofmetabolism in all vertebrates. In particular, hypothalamic arcuateproopiomelanocortin (POMC) neurons sense the energy status ofthe organism by the integration of peripheral signals such as leptin,glucose and insulin. POMC derived peptides such as β-endorphinand α-MSH, are involved in many physiological functions includingreproduction, energy homeostasis and reward. POMC deficientpatients and mice are hiperfagic, obese and diabetic. The role ofPOMC neurons in glucose homeostasis has been well established,but it remains to be elucidated if hypothalamic POMC peptide is directlyinvolved, especially considering that these neurons may alsoco-secrete other neuropeptides and neurotransmitters. To addressthis question we used a mouse line that bears a reversible mutationthat prevents arcuate Pomc expression (arcPomc-/-). To determinethe role of central POMC in maintaining glucose homeostasis independentlyof body weight, we subjected arcPomc-/- weanling mice(before overweight development), to a glucose tolerance test. Ourresults show that mutant mice have reduced glucose tolerance comparedto their wild type siblings (p