Salt-Sensitive Hypertension Response to Hormone Replacement in Adult Ovariectomized Wistar Rats

CLAUDIA SILBERSTEIN; LUIS A DI CIANO1, PABLO J AZURMENDI1, SANDRA G VLACHOVSKY1, GISELE A MOIRÓN1, ALEJANDRO F CELÍA1, ELISABET M ODDO1, ELVIRA E ARRIZURIETA1, 3, CLAUDIA M SILBERSTEIN2 AND FERNANDO R IBARRA1,2; FERNANDO R IBARRA

Mar del Plata

Congreso; Reunión Anual de La Sociedad Argentina de Investigación Clínica; 2016

Sociedad Argentina de Investigación Clínica

Ovariectomy in adult Wistar rats induces a decrease in the expression of D1-like dopamine receptors (D1DR), in Cyp450 4A (Cyp4A) expression and activity and an increase in the dephosphorylation of Na+, K+-ATPase (NKA Ser-23) in renal tissue. As a consequence, oVx rats, that otherwise have a normal mean arterial pressure (MAP), are unable to handle a sodium load (NaCL 1%) and develop sodium-sensitive hypertension. In this work we have studied whether estrogen or progesterone replacement can modify the response to HS intake in oVx rats. Accordingly, oVx rats were supplemented with pellets designed to be released over a 14-day period and received normal (NS) or HS intake. Under estrogen replacement rats were able to increase sodium excretion and to maintain a normal MAP (p