Changes in serum uric acid levels during normal and pathological pregnancies

BALCONI SILVIA; DAMIANO ALICIA E; ORTIZ MARÍA; COROMINAS ANA; MARTÍNEZ NORA

Mar del Plata

Congreso; LXI Reunión Científica Anual de la Sociedad Argentina de Investigación Clínica; 2016

Determination of serum uric acid (SUA) is used to monitor maternal renal function during pregnancy. Despite its great biological variability in non pregnant and in pregnant healthy women, most laboratories reported as reference range, those of non pregnant women, a fact that promotes misinterpretation of the results.Our aim was to describe the range of SUA in pregnant women throughout pregnancy in normal and pathological conditions.We conducted a prospective approach in which we studied all patients who attended her pregnancy in the Hospital Posadas during 2014. SUA (mg/dl), urea and creatinine were measured along gestation and were evaluated in the context of normal or pathological pregnancy. In diabetic pregnant women (n=164) SUA increased statistically after the 30th week compared to normal pregnancy (3.92±0.85 vs 3.56±0.77, p=0.014); but at the end of pregnancy, SUA were similar to normal ones. In women with gestational hypertension without preeclampsia (PE) (n=32) we observed a continuous increase of SUA levels but the difference between the end and the beginning of pregnancy was lower than 1.5. In women with PE (n=40), SUA increased progressively with a difference between the 30th week and the beginning of gestation higher than 1.5 (p=0.0001) and the highest increased at the end of the pregnancy (3.92±0.95 vs 6.04±1.40, p