IFIBIO HOUSSAY   25014
INSTITUTO DE FISIOLOGIA Y BIOFISICA BERNARDO HOUSSAY
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Time course of motor memory consolidation in visuomotor adaptation
Autor/es:
P. CAFFARO, J. VILLALTA, V. DELLA MAGGIORE
Lugar:
Washington, DC
Reunión:
Congreso; Annual meeting of the Society for Neuroscience; 2014
Institución organizadora:
Society for Neuroscience
Resumen:
Visuomotor adaptation is the process by which our motor system adjusts movements to a novel environment. Although abundant evidence points to the formation of long-term motor memories for this type of learning, several previous studies have failed at characterizing the time course of memory consolidation using behavioral protocols of retrograde interference (e.g. Caithness et. al., 2004). This may in part be due to the fact that anterograde effects are very strong, often masking retrograde effects. Here, we took advantage of this phenomenon to explore the time course of motor memory consolidation. Subjects adapted to two opposite visual rotations of 30 degrees following a protocol of anterograde interference. They performed 6 blocks of pointing movements to 8 visual targets using a joystick (1 cycle = 8 targets; 11 cycles per block). Participants were divided in 6 groups, which experienced a clockwise rotation (A), followed, after a variable interval of 1min, 15min, 1h, 3h, 5,5h and 24 h, by a counterclockwise rotation (B). The rate of learning for A and B was computed by fitting individual visuomotor error for all cycles using a single exponential function with a constant (Zarahn et. al., 2008). We assumed that a reduction in the rate of learning of B would reflect the consolidation of the memory for A. In contrast to our own predictions and to previous studies on sensorimotor adaptation (Shadmehr et. al., 1997; Krakauer et. al., 2005), our preliminary results point to a non-monotonic pattern of anterograde interference. References: - Caithness et. al., 2004 J Neurosci. 2004 Oct 6;24(40):8662-71. - Zarahn et. al., 2008 J Neurophysiol. 2008 Nov;100(5):2537-48. - Shadmehr et. al., 1997 J Neurosci. 1997 Jan 1;17(1):409-19. - Krakauer et. al., 2005 J Neurosci. 2005 Jan 12;25(2):473- 8.