IFIBIO HOUSSAY   25014
INSTITUTO DE FISIOLOGIA Y BIOFISICA BERNARDO HOUSSAY
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Arc IS REQUIRED FOR PATTERN SEPARATION ACROSS THE SPATIAL AND THE OBJECT DOMAINS IN THE DENTATE GYRUS AND PERIRHINAL CORTEX
Autor/es:
MAGDALENA MIRANDA; FACUNDO MORICI; NOELIA WEISSTAUB; PEDRO BEKINSCHTEIN
Lugar:
Cordoba
Reunión:
Congreso; Congreso SAN 2014; 2014
Institución organizadora:
Sociedad Argentina de investigación en Neurociencias
Resumen:
Successful memory involves not only remembering information over time but also keeping memories distinct and less confusable. The ability to separate the components of memories into distinct memory representations relies on pattern separation, a computational process by which differences are amplified to disambiguate similar events. Despite the importance of this mnemonic function, the molecular mechanisms and signals necessary for the behavioral manifestations of this process remain unknown. Although pattern separation has been localized to the dentate gyrus of the hippocampus and shown to occur in a spatial domain, this cognitive function is thought to take place also during processing of other types of information. The perirhinal cortex (PRH) is involved in the acquisition and storage of object memories. Thus, we hypothesized that this structure is involved in pattern separation of object memories.. In this work, we used both a hippocampal-dependent and a PRH-dependent task and manipulated the load of pattern separation during Information encoding. We showed that acquisition/ consolidation of Pattern-separated memories depend on the expression of Arc on both tasks, and that interaction between Arc and BDNF is necessary for successful pattern separation. These findings suggest that Arc, an immediate early gene known to regulate synaptic plasticity and mediate memory formation, is involved in the molecular mechanisms underlying pattern separation.