IFIBIO HOUSSAY   25014
INSTITUTO DE FISIOLOGIA Y BIOFISICA BERNARDO HOUSSAY
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Role of hypothalamic proopiomelanocortin in the regulation of glycemia
Autor/es:
ALSINA RAMIRO; KUHBACHER WILSON ALEXIS; BUMASCHNY VF
Lugar:
Chascomús
Reunión:
Jornada; XVI Jornadas Anuales de la Sociedad Argentina de Biología (SAB); 2014
Institución organizadora:
Sociedad Argentina de Biología
Resumen:
Elucidating the central nervous system mechanisms that participate in the control of glucose homeostasis could lead to new therapies for diabetes. Some of hypothalamic proopiomelanocortin (POMC) derived peptides are anorexigenic. POMC deficient patients and mice are obese and diabetic. However, it is not clear if POMC has a direct role in glucose homeostasis. To address this issue we used a mouse line that bears a reversible mutation that prevents arcuate Pomc expression (arcPomc-/-). To determine the role of central POMC in maintaining glucose homeostasis independently of body weight we subjected arcPomc-/- weanling mice (that are still lean) to a glucose tolerance test. Our results show that mutant mice have reduced glucose tolerance compared to their wild type siblings (glycemia at 120´: 165 ± 10 mg/dL, vs 125 ± 7 mg/dL, arcPOMC-/- vs WT respectively, p